Glycosyl Phosphatidylinositol-Anchored C34 Peptide Derived From Human Immunodeficiency Virus Type 1 Gp41 Is a Potent Entry Inhibitor
نویسندگان
چکیده
منابع مشابه
Membrane-anchored peptide inhibits human immunodeficiency virus entry.
Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.
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ژورنال
عنوان ژورنال: Journal of Neuroimmune Pharmacology
سال: 2016
ISSN: 1557-1890,1557-1904
DOI: 10.1007/s11481-016-9681-x